This article explores the concept of “mindscape” as a driver for heritage regeneration, addressing the growing mental health crisis exacerbated by urban isolation and environmental disconnection. Drawing on the Council of Europe conventions on “Landscape” (Florence, 2000) and the “Value of Cultural Heritage” (Faro, 2005), the research investigates how cultural and natural heritage can foster emotionally healthy and resilient urban districts. Focusing on Vigne Nuove, a 1970s public housing complex in Rome, the study employs the mindscape framework to analyze immaterial layers of heritage, integrating emotional, affective, and perceptual dimensions into urban transformation processes. By operationalizing mindscapes, the research aims to better understand heritage sites in their multiple dimensions, as well as to mitigate urban challenges, redefine spatial production, and create new urban commons, ultimately contributing to a topography of collective wellbeing and adaptive urban futures.